Robert A Hegele Selected Research

Metabolic Syndrome (Dysmetabolic Syndrome X)

1/2022	Effective, disease-modifying, clinical approaches to patients with mild-to-moderate hypertriglyceridaemia.
1/2018	The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes.
1/2018	Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract.
2/2015	Hypertriglyceridemia in the genomic era: a new paradigm.
1/2013	Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population.
10/2009	Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance.
3/2009	Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community.
7/2008	Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project.
4/2007	Hypertriglyceridemia: its etiology, effects and treatment.
9/2006	Genetic determinants of the metabolic syndrome.

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Robert A Hegele Research Topics

Disease

76	Cardiovascular Diseases (Cardiovascular Disease) 06/2024 - 05/2004
51	Hypertriglyceridemia 06/2024 - 01/2002
46	Dyslipidemias (Dyslipidemia) 03/2024 - 12/2002
41	Atherosclerosis 01/2023 - 03/2002
40	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2024 - 03/2002
25	Type 2 Diabetes Mellitus (MODY) 10/2023 - 01/2002
24	Pancreatitis 04/2024 - 01/2006
22	Hypertension (High Blood Pressure) 10/2021 - 06/2004
22	Insulin Resistance 01/2021 - 02/2002
18	Homozygous Familial Hypercholesterolemia 03/2024 - 02/2005
17	Hypercholesterolemia 01/2024 - 02/2005
16	Hyperlipoproteinemia Type I (Lipoprotein Lipase Deficiency, Familial) 04/2024 - 03/2002
15	Obesity 01/2022 - 02/2002
15	Lipodystrophy 01/2022 - 12/2002
14	Myocardial Infarction 01/2024 - 05/2007
14	Coronary Artery Disease (Coronary Atherosclerosis) 12/2023 - 03/2004
13	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 10/2003
12	Hyperlipidemias (Hyperlipidemia) 01/2021 - 01/2002
12	Xanthomatosis (Xanthoma) 01/2018 - 10/2002
11	Stroke (Strokes) 01/2024 - 05/2003
11	Muscular Diseases (Myopathy) 06/2023 - 03/2007
11	Familial Partial Lipodystrophy (Dunnigan Syndrome) 12/2014 - 03/2002
10	Genetic Risk Score 11/2023 - 01/2013
10	Abetalipoproteinemia (Bassen Kornzweig Syndrome) 01/2023 - 08/2010
9	Hypobetalipoproteinemias (Hypobetalipoproteinemia) 01/2023 - 04/2003
8	Inborn Genetic Diseases (Disease, Hereditary) 01/2023 - 09/2004
8	Vascular Diseases (Vascular Disease) 04/2022 - 04/2003
8	Diabetes Mellitus 01/2022 - 05/2007
8	Chronic Renal Insufficiency 01/2021 - 05/2007
7	Coronary Disease (Coronary Heart Disease) 09/2019 - 03/2002
6	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 08/2013
6	Cognitive Dysfunction 03/2024 - 01/2016
6	Cerebrovascular Disorders (Cerebrovascular Occlusion) 12/2023 - 05/2007
6	Neoplasms (Cancer) 12/2018 - 10/2004
5	Hyperlipoproteinemias 01/2019 - 09/2007
5	Heart Failure 01/2018 - 05/2007
5	Isolated Systolic Hypertension 01/2017 - 05/2007
4	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 05/2009
4	Acute Coronary Syndrome 05/2023 - 12/2015
4	Hyperlipoproteinemia Type III (Broad Beta Disease) 01/2023 - 01/2019
4	Myalgia 02/2021 - 06/2009
4	Inflammation (Inflammations) 01/2021 - 08/2009
4	Progeria (Hutchinson Gilford Syndrome) 10/2020 - 10/2003
4	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 01/2019 - 07/2002
4	Rhabdomyolysis 01/2016 - 03/2007
4	Atherosclerotic Plaque (Atheroma) 03/2013 - 02/2004

Drug/Important Bio-Agent (IBA)

79	LDL CholesterolIBA 03/2024 - 03/2002
68	Triglycerides (Triacylglycerol)IBA 06/2024 - 01/2002
62	LipidsIBA 03/2024 - 08/2003
41	oxidized low density lipoproteinIBA 03/2024 - 02/2004
37	CholesterolIBA 10/2023 - 02/2005
37	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2023 - 03/2007
36	HDL CholesterolIBA 01/2023 - 07/2002
30	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 01/2002
28	Lipoproteins (Lipoprotein)IBA 06/2023 - 01/2002
27	ApolipoproteinsIBA 03/2024 - 07/2002
23	LDL Lipoproteins (beta Lipoproteins)IBA 01/2023 - 02/2004
19	Proteins (Proteins, Gene)FDA Link 01/2023 - 07/2002
17	Apolipoproteins B (ApoB)IBA 01/2024 - 04/2003
16	Lamin Type A (Lamin A)IBA 10/2020 - 12/2002
14	LDL Receptors (LDL Receptor)IBA 05/2023 - 02/2005
13	Ezetimibe (Zetia)FDA Link 04/2022 - 10/2005
12	Apolipoproteins E (ApoE)IBA 03/2024 - 02/2008
12	Insulin (Novolin)FDA Link 12/2021 - 04/2002
11	Lipoprotein(a)IBA 03/2024 - 10/2008
10	Biomarkers (Surrogate Marker)IBA 12/2023 - 05/2004
10	Apolipoprotein C-II (ApoC2)IBA 01/2020 - 06/2011
10	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 04/2002
9	Apolipoprotein C-IIIIBA 04/2024 - 01/2016
9	microsomal triglyceride transfer proteinIBA 03/2022 - 08/2010
9	BMS201038IBA 01/2022 - 01/2013
9	PPAR gammaIBA 10/2009 - 12/2002
8	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2023 - 03/2002
7	Proprotein Convertase 9IBA 03/2024 - 12/2013
7	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2013 - 07/2002
6	ISIS 304801IBA 02/2024 - 12/2015
6	HDL LipoproteinsIBA 01/2023 - 07/2002
6	PCSK9 InhibitorsIBA 01/2022 - 01/2018
6	Angiotensin Receptor AntagonistsIBA 01/2018 - 05/2007
6	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2018 - 05/2007
6	EnzymesIBA 10/2015 - 12/2005
5	evolocumabIBA 03/2024 - 05/2019
5	ChylomicronsIBA 04/2022 - 03/2002
5	VitaminsIBA 03/2022 - 10/2004
5	O(4)-methylthymidine triphosphateIBA 03/2022 - 07/2016
5	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 03/2021 - 11/2013
5	SubtilisinIBA 03/2021 - 11/2013
5	Lipase (Acid Lipase)FDA Link 01/2020 - 03/2002
5	Cholesterol Ester Transfer ProteinsIBA 01/2018 - 02/2008
5	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2016 - 05/2007
5	1,4-dihydropyridine (dihydropyridine)IBA 07/2011 - 05/2007
4	Monoclonal AntibodiesIBA 03/2024 - 02/2020
4	Small Interfering RNA (siRNA)IBA 12/2023 - 01/2015
4	Antihypertensive Agents (Antihypertensives)IBA 01/2022 - 01/2003
4	Fibric Acids (Fibrates)IBA 02/2020 - 10/2007
4	LeptinIBA 01/2018 - 01/2003
4	mipomersenIBA 12/2015 - 10/2010

Therapy/Procedure

59	Therapeutics 04/2024 - 02/2004
4	Fat-Restricted Diet (Diet, Fat Restricted) 11/2022 - 08/2012
4	Plasma Exchange 01/2022 - 08/2012